QuickView for Presenilin 2;jsessionid=DEFD2F3E260E73A41DBC80FB7456E0AE;jsessionid=D8DA543BE19A0B643185D40363EDF4AD (gene)
- Gene Symbol:
- Psen2
Rattus norvegicus - Full name:
- presenilin 2
- Synonyms:
- presenilin-2, PS-2
- Genomic Location:
- Chr 13: 95934240-95960366
- Description:
-
mutations in human homolog responsible for chromosome 1-linked familial Alzheimer's disease; expression increased during brain development but decreased in the adult
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
| Transcripts Names |
|---|
| NM_031087 |
| XM_006250407 |
| XM_006250405 |
| XM_017598939 |
| XM_008769877 |
| XM_006250408 |
| XM_006250410 |
GO Molecular Function
aspartic-type peptidase activity | hydrolase activity | catalytic activity | aspartic endopeptidase activity, intramembrane cleaving | aspartic-type endopeptidase activity | endopeptidase activity | peptidase activity
GO Biological Process
positive regulation of immune response | negative regulation of signaling receptor activity | negative regulation of phosphorylation | brain development | membrane protein proteolysis | limb development | Notch signaling pathway | molting cycle | heart process | immune response-regulating signaling pathway | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | regulation of programmed cell death | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | myeloid cell differentiation | neuron cellular homeostasis | negative regulation of cellular process | negative regulation of kinase activity | neural tube patterning | protein processing | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | cell differentiation | immune response-activating cell surface receptor signaling pathway | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | respiratory tube development | T cell receptor signaling pathway | positive regulation of receptor recycling | nervous system development | positive regulation of protein catabolic process | negative regulation of protein phosphorylation | cellular chemical homeostasis | negative regulation of proteolysis | pattern specification process | cellular process | cell fate specification | localization | cellular homeostasis | negative regulation of ubiquitin-dependent protein catabolic process | limb morphogenesis | regulation of ubiquitin-protein transferase activity | protein transport | negative regulation of signaling | metal ion transport | immune system development | negative regulation of nucleic acid-templated transcription | macromolecule localization | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of binding | anatomical structure homeostasis | negative regulation of apoptotic signaling pathway | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | negative regulation of ubiquitin-protein transferase activity | regulation of protein complex assembly | heart contraction | aspartic-type peptidase activity | positive regulation of cellular protein metabolic process | epithelium development | negative regulation of epidermal growth factor receptor signaling pathway | calcium ion homeostasis | negative regulation of cellular protein catabolic process | T cell activation | head development | positive regulation of cellular protein catabolic process | muscle contraction | response to stimulus | thymus development | embryonic limb morphogenesis | respiratory system development | regulation of peptidyl-tyrosine phosphorylation | skin morphogenesis | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | membrane protein ectodomain proteolysis | leukocyte activation involved in immune response | negative regulation of protein kinase activity | regulation of protein ubiquitination | hematopoietic progenitor cell differentiation | positive regulation of proteolysis involved in cellular protein catabolic process | divalent metal ion transport | positive regulation of proteolysis | cellular nitrogen compound metabolic process | immune response-activating signal transduction | blood circulation | brain morphogenesis | negative regulation of metabolic process | hemopoiesis | modulation of chemical synaptic transmission | dorsal/ventral pattern formation | embryo development | metal ion homeostasis | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | leukocyte differentiation | locomotion | lung alveolus development | regulation of protein tyrosine kinase activity | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | learning or memory | regulation of catalytic activity | regulation of phosphorylation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | organic substance transport | nervous system process | myeloid leukocyte differentiation | positive regulation of cellular metabolic process | cellular ion homeostasis | animal organ morphogenesis | regulation of nitrogen compound metabolic process | peptide transport | cellular amide metabolic process | regulation of transcription by RNA polymerase II | negative regulation of binding | negative regulation of extrinsic apoptotic signaling pathway | cognition | neural tube development | regulation of cellular protein metabolic process | positive regulation of proteasomal protein catabolic process | T cell activation involved in immune response | protein maturation | epidermis development | regulation of apoptotic signaling pathway | skin development | cation homeostasis | aspartic endopeptidase activity, intramembrane cleaving | chordate embryonic development | cellular cation homeostasis | positive regulation of extrinsic apoptotic signaling pathway | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of protein kinase activity | cell activation involved in immune response | regulation of protein metabolic process | dorsal/ventral neural tube patterning | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | peptide metabolic process | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | negative regulation of protein ubiquitination | striated muscle contraction | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | embryonic morphogenesis | lymphocyte activation | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | regulation of signaling receptor activity | regulation of epidermal growth factor-activated receptor activity | activation of immune response | protein metabolic process | regionalization | hair cycle | gland development | aspartic-type endopeptidase activity | regulation of kinase activity | anatomical structure development | cell surface receptor signaling pathway | Notch receptor processing | metabolic process | cell fate commitment | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | positive regulation of coagulation | amide transport | hair cycle process | chemical homeostasis | calcium ion transport | behavior | positive regulation of cell death | immune response | negative regulation of ERBB signaling pathway | negative regulation of protein complex assembly | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | forebrain development | negative regulation of cellular protein metabolic process | gene expression | positive regulation of programmed cell death | ion homeostasis | skin epidermis development | regulation of phosphate metabolic process | antigen receptor-mediated signaling pathway | establishment of protein localization | cell activation | lung development | anatomical structure formation involved in morphogenesis | memory | negative regulation of protein catabolic process | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | somite development | regulation of transcription, DNA-templated | regulation of protein binding | endopeptidase activity | regulation of ERBB signaling pathway | negative regulation of peptidyl-tyrosine phosphorylation | protein localization | cellular protein metabolic process | anatomical structure morphogenesis | cation transport | endoplasmic reticulum calcium ion homeostasis | segmentation | developmental process | negative regulation of epidermal growth factor-activated receptor activity | negative regulation of transcription by RNA polymerase II | tube development | regulation of receptor recycling | amyloid-beta metabolic process | cellular metal ion homeostasis | somitogenesis | central nervous system development | positive regulation of metabolic process | regulation of synaptic plasticity | ion transport | cardiac muscle contraction | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | peptidase activity | regulation of cell death | negative regulation of protein tyrosine kinase activity | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | negative regulation of proteolysis involved in cellular protein catabolic process | divalent inorganic cation homeostasis | regulation of cellular component organization | positive regulation of apoptotic signaling pathway | muscle system process | positive regulation of signaling | hair follicle development | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | integral component of membrane | organelle inner membrane | chromosome | intracellular membrane-bounded organelle | apical plasma membrane | somatodendritic compartment | organelle membrane | sarcomere | microtubule organizing center | nuclear membrane | chromosome, centromeric region | cell body | cell | neuronal cell body | nuclear inner membrane | kinetochore | intrinsic component of membrane | myofibril | cytoplasm | intracellular organelle | endoplasmic reticulum | contractile fiber | apical part of cell | centrosome | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | endomembrane system | endoplasmic reticulum membrane | plasma membrane | nuclear envelope | cilium | perinuclear region of cytoplasm | microtubule cytoskeleton | cytoplasmic region | integral component of plasma membrane | Golgi membrane | cell cortex | membrane-bounded organelle | nucleus | organelle | I band | cell periphery | Z disc | cytosol | cytoskeleton | intracellular | membrane | supramolecular complex | ciliary basal body | intrinsic component of plasma membrane
